Peptide Direct UK compiles mechanism-of-action summaries and research context on compounds studied in metabolic, longevity, recovery, and neuroscience literature.
Compounds studied for their role in glucose regulation, appetite signalling, and cellular energy production — spanning approved metabolic medicines and early-stage mitochondrial research.
A triple hormone receptor agonist studied in Phase 3 clinical trials for its effects on body weight and metabolic markers. It engages three separate incretin-related pathways simultaneously, distinguishing it from single- or dual-agonist compounds.
Weight regulation, insulin sensitivity, lipid metabolism.
A GLP-1 receptor agonist approved by regulators for type 2 diabetes and chronic weight management under specific brand names and prescribing guidelines. It slows gastric emptying and enhances glucose-dependent insulin secretion.
Glycaemic control, appetite regulation, cardiometabolic risk.
A dual incretin receptor agonist approved for type 2 diabetes and weight management. Combining GIP and GLP-1 activity has been studied for producing greater metabolic effect than GLP-1 agonism alone.
Combined incretin signalling, glycaemic and weight outcomes.
An amylin analogue studied for its effect on satiety signalling, frequently investigated in combination with GLP-1 agonists to assess additive effects on food intake and body weight.
Satiety signalling, combination therapy research.
A peptide encoded within mitochondrial DNA, studied for activity on AMPK signalling and cellular energy homeostasis. Early research has explored it as an "exercise mimetic" candidate in metabolic stress models.
AMPK activation, mitochondrial signalling, exercise physiology models.
A coenzyme central to redox reactions and cellular energy metabolism in every living cell. Declining NAD+ levels with age are studied in relation to sirtuin activity, DNA repair capacity, and mitochondrial function.
Cellular metabolism, sirtuin pathways, aging biology.
Peptides and small molecules examined in longevity science for effects on telomere biology, growth hormone signalling, mitochondrial density, and dermal structure.
A synthetic four–amino-acid peptide originally researched by Russian gerontologists as a pineal gland regulator. Studied for possible effects on telomerase activity and circadian melatonin rhythm in laboratory and small clinical cohorts.
Telomerase activity, pineal function, circadian regulation.
A growth-hormone-releasing hormone analogue approved for reducing excess abdominal fat in HIV-associated lipodystrophy. It stimulates the pituitary to release growth hormone through the natural GHRH receptor pathway.
Visceral fat reduction, GH axis stimulation.
A synthetic small molecule — not a peptide — that activates ERRα/β/γ, transcription factors involved in mitochondrial biogenesis. Early rodent studies have explored it as an exercise-mimetic candidate.
Mitochondrial biogenesis, endurance-pathway signalling.
A naturally occurring copper peptide complex studied extensively in dermatology for its role in collagen synthesis, wound healing, and gene expression modulation. Used in cosmetic formulations as well as research settings.
Skin remodelling, wound repair, gene expression signalling.
A modified growth-hormone-releasing hormone analogue studied for its ability to increase pulsatile growth hormone and IGF-1 release. Exists in variants with and without a drug affinity complex (DAC) altering its half-life.
GH pulsatility, IGF-1 signalling, pituitary research.
Growth-hormone secretagogues and tissue-repair peptides referenced in strength, recovery, and regenerative research, including informal "stack" names used in enthusiast literature.
Not a clinical or regulatory designation. This is an enthusiast term generally referring to a pairing of tissue-repair peptides discussed in recovery-focused research communities. Each constituent has a distinct, separately studied mechanism.
Soft-tissue repair signalling (individually studied components).
An informal enthusiast label, not a defined clinical compound, generally referring to a combination built around copper peptide research for skin appearance. Composition varies by source.
Dermal collagen signalling (individually studied components).
A growth hormone secretagogue studied for stimulating GH release with relative selectivity, meaning it produces less effect on cortisol and prolactin than earlier-generation secretagogues in research models.
Selective GH release, ghrelin receptor pharmacology.
A modified version of insulin-like growth factor 1 engineered for reduced binding to IGF-binding proteins, extending its half-life in research settings. Studied in relation to muscle protein synthesis pathways.
IGF-1 receptor signalling, muscle protein synthesis models.
A peptide fragment derived from a protective protein found in gastric juice, studied largely in animal models for effects on tendon, ligament, and gut-lining repair. Human clinical data remains limited.
Angiogenesis, tendon/ligament healing models, gut barrier research.
Neuropeptides examined for effects on sleep architecture, cognitive performance, and neuroprotection.
A neuropeptide first isolated from the cerebral venous blood of rabbits during induced slow-wave sleep. Research has examined its relationship to delta-wave sleep patterns and stress-response modulation, with limited modern human data.
Slow-wave sleep architecture, stress-axis modulation.
A synthetic peptide derived from a fragment of adrenocorticotropic hormone, approved as a prescription nootropic/neuroprotective agent in Russia. Studied for effects on BDNF expression and cognitive performance; not approved in the UK or US.
BDNF signalling, neuroprotection, cognitive research models.
A synthetic analogue of alpha-MSH studied for its effect on melanocyte stimulation and sexual arousal pathways. Research and regulatory bodies, including the UK's MHRA, have issued specific warnings about unregulated use, citing reports of nausea, blood-pressure changes, and new or changing moles.
Melanocortin receptor pharmacology, pigmentation pathways.
Reach out with questions about the studies and mechanisms referenced on this page. We respond to research and educational enquiries only.
